Rosalind Dalefield


Diplomate of the American Board of Toxicology

Diplomate of the American Board of Veterinary Toxicology



For the first time in New Zealand, a Consultant Toxicologist with two Board certifications in Toxicology, the science of poisons and poisoning.

Offering clients the benefit of my expertise in:


I am highly experienced in the design, conduct, interpretation and reporting of mammalian nonclinical toxicology studies including acute and escalating dose range-finding studies; LD50 studies; toxicokinetics studies; acute, subchronic and chronic studies; and conventional and transgenic carcinogenicity studies.  Dose routes included oral gavage; oral capsule; oropharyngeal deposition; intranasal liquid or spray; dermal; subcutaneous depot; intramuscular; intraperitoneal; inhalation of powder or liquid aerosol; intravenous bolus and intravenous infusion.  Species used included Beagle dogs, Cynomolgus macaques, Rhesus macaques, guinea pigs, and a wide variety of strains of laboratory rat and mouse including all the transgenic strains of mouse currently approved by the USFDA for carcinogenicity assessment.

Methods included in study designs and reports included toxicokinetics, electrocardiography, respiratory measurements, histomorphometry, polymerase chain reaction, antibody determination, immunological challenge, clinical pathology including broncho-alveolar lavage, and anatomic pathology including special stains.

 I have performed studies  in regulatory compliance for a range of regulatory bodies including USFDA-CDER, USFDA-CVM, OECD, and MHLW (Japan).  I am also familiar with, and am keeping track of advances in, ICH Guidelines.  I have twice had studies audited on-site by the USFDA, with no adverse findings in either study.

I have frequently been commended by clients for excellent command of scientific English, for offering suggestions that saved them money and/or improved the scientific quality of their reports, and for timely production of study reports. Clients included many major pharmaceutical companies such as Glaxo Smith Kline, Johnson and Johnson, Eli Lilly, Wyeth, Sankyo and Hoffman-La Roche, as well as many smaller pharmaceutical companies, and also the National Toxicology Program (NTP) of the National Institute of Environmental Health and Safety (NIEHS), USA.  I am experienced in the design of study packages for start-up pharmaceutical companies, to take a drug candidate from first in vivo studies to IND approval and beyond.

Contact me to discuss how I can help you with drug development and international regulatory approval!


I first gained experience in environmental toxicology when I worked with the Hazardous Substances Research Center at Kansas State University, dealing with a number of contaminated sites.  Problems I worked on included aquifer contamination in Kansas and in Missouri; a leaking landfill in Nebraska which was affecting plant life and draining into a major river; decommissioned bombing ranges in Colorado and South Dakota; selenium-rich soils and vegetation in South Dakota; and a decommissioned army base in South Dakota, at which problems included cadmium contamination, petroleum hydrocarbon contamination, unexploded ordnance, buried nitrogen mustard, and community concerns about the history of the base for storage of nerve gases, vesicants and tear gases. My services to the Hazardous Substances Research Center included participating in site assessments, literature reviews, preparation and review of risk assessments, review of laboratory results, giving informative presentations to community groups and answering their questions, and writing informative pamphlets and handouts.

 In addition to my work with the Hazardous Substances Research Center I participated in providing a toxicology consultancy service by telephone, backed up by our toxicology laboratory at Kansas State University.  Environmental hazards addressed included metal contamination (e.g. lead, selenium, zinc, mercury) and metal poisonings in wildlife and livestock, petroleum hydrocarbon contamination, nitrates in water supplies, and organophosphate contaminations and consequent toxicoses in wildlife and livestock.

Contact me to discuss how I can help you with environmental toxicology issues!


I have a total of 13 years' experience as a toxicologist, including operating a toxicology laboratory single-handed, and developing another.  I have provided expertise on a wide range of toxicological hazards including those in the workplace; those in air, soil and water; poisonous plants; venomous insects and vertebrates; household hazards; pharmaceutical candidates and pharmaceuticals that are on the market; a wide range of biocides including pesticides, herbicides, rodenticides and molluscicides; and hazards to pets, livestock and wildlife. I can offer extensive experience in literature review and risk assessment.  I can help with questions about exposure, absorption, metabolism, excretion and effects of poisons, both manmade and natural, in human beings and in a wide range of other species, both domesticated and wild.

The status of Diplomate of the American Board of Toxicology (DABT) is regarded internationally as the 'gold standard' in toxicology.  Gaining this status requires demonstration of a wide-ranging and comprehensive knowledge of all aspects of toxicology, which is a huge and varied field.  Even the process of gaining approval to sit the three tough examinations requires years of fulltime work and study in toxicology.  In New Zealand, the term 'toxicologist' is not a restricted term, so anyone in New Zealand can call themselves a toxicologist.  However, 'toxicologists' who are not Board Diplomates may not have the breadth and depth of knowledge required to gain the status of Diplomate.  They may have little or no experience, or may have spent years studying the toxicity of very few chemicals without ever having learnt or understood the principles of the science of  toxicology.  If you're looking for expertise in toxicology, you can be far more confident of finding it if you seek the advice of a DABT.

Contact me to discuss how I can help you with general toxicology issues!


In addition to being a Diplomate of the American Board of Toxicology (DABT) I am also a Diplomate of the American Board of Veterinary Toxicology (DABVT).  The American Board of Toxicology is one of the Specialty Boards of the American Veterinary Medical Association (AVMA).  Just as the status of DABT is the gold standard of knowledge and expertise in general toxicology, the status of DABVT is the gold standard of knowledge and expertise in toxicology within veterinary medicine, not only in the USA but also in Australia and New Zealand.  If you're looking for expertise in veterinary toxicology, you can't do better than a DABVT.

I do not have a veterinary practice, so I cannot accept or treat veterinary patients myself.  However, I am happy to offer review of past or current cases in veterinary toxicology, to help veterinarians dealing with toxicoses or to answer questions pet owners or farmers may have about past or current veterinary management of toxicoses in their animals.  I can also offer advice on husbandry issues to minimise the risk of poisoning. I hold a PhD in veterinary pathology and I can also help with the interpretation of veterinary pathology reports as they relate, or may relate, to poisoning.

Contact me to discuss how I can help you with veterinary toxicology issues!